Hemoglobin C Trait
About 1 out of every 40 African-Americans has hemoglobin C trait. This trait also affects people whose ancestors came from Italy, Greece, Africa, Latin America, and the Caribbean region.
However, it is possible for a person of any race or nationality to have hemoglobin C trait.
People with hemoglobin C trait have red blood cells that have normal hemoglobin A and an abnormal hemoglobin. The abnormal hemoglobin is called hemoglobin C. People with hemoglobin C trait have slightly more hemoglobin A than hemoglobin C. People with Hemoglobin C trait do not have health problems related to having the trait.
People with hemoglobin C do not have Hemoglobin C disease or sickle cell disease. They cannot develop these diseases later in life. They can pass hemoglobin C trait to their children.
If a person with hemoglobin C trait (hgb AC) has a child with a person with sickle cell trait (hgb AS), they have a 25% chance with each pregnancy to have a child with a form of sickle cell disease called sickle cell C disease or hemoglobin SC disease (hgb SC).
People who have this form of SCD inherit a sickle cell gene (“S”) from one parent and from the other parent a gene for an abnormal hemoglobin called “C”. Hemoglobin is a protein that allows red blood cells to carry oxygen to all parts of the body. This is usually a milder form of SCD.
Hemoglobin D Trait
People with hemoglobin D trait have red blood cells that have normal hemoglobin A and an abnormal hemoglobin. The abnormal hemoglobin is called hemoglobin D. People with hemoglobin D trait have slightly more hemoglobin A than hemoglobin D. People with Hemoglobin D trait do not have health problems related to having the trait.
People with hemoglobin D trait do not have Hemoglobin D disease or sickle cell disease. They cannot develop these diseases later in life. They can pass hemoglobin D trait to their children.
If a person with hemoglobin D trait (hgb AD) has a child with a person with sickle cell trait (hgb AS), they have a 25% chance with each pregnancy to have a child with a form of sickle cell disease called sickle cell D disease or hemoglobin SD disease (hgb SD).
There are also other hemoglobin traits that in combination with sickle cell trait (hgb AS) can create other forms of sickle cell disease. This can include hemoglobin E trait or hemoglobin O trait. People who have these forms of SCD inherit one sickle cell gene (“S”) and one gene from an abnormal type of hemoglobin (“E”, or “O”). Hemoglobin is a protein that allows red blood cells to carry oxygen to all parts of the body. The severity of these rarer types of SCD varies.
However, it is possible for a person of any race or nationality to have hemoglobin C trait.
People with hemoglobin C trait have red blood cells that have normal hemoglobin A and an abnormal hemoglobin. The abnormal hemoglobin is called hemoglobin C. People with hemoglobin C trait have slightly more hemoglobin A than hemoglobin C. People with Hemoglobin C trait do not have health problems related to having the trait.
People with hemoglobin C do not have Hemoglobin C disease or sickle cell disease. They cannot develop these diseases later in life. They can pass hemoglobin C trait to their children.
If a person with hemoglobin C trait (hgb AC) has a child with a person with sickle cell trait (hgb AS), they have a 25% chance with each pregnancy to have a child with a form of sickle cell disease called sickle cell C disease or hemoglobin SC disease (hgb SC).
People who have this form of SCD inherit a sickle cell gene (“S”) from one parent and from the other parent a gene for an abnormal hemoglobin called “C”. Hemoglobin is a protein that allows red blood cells to carry oxygen to all parts of the body. This is usually a milder form of SCD.
Hemoglobin D Trait
People with hemoglobin D trait have red blood cells that have normal hemoglobin A and an abnormal hemoglobin. The abnormal hemoglobin is called hemoglobin D. People with hemoglobin D trait have slightly more hemoglobin A than hemoglobin D. People with Hemoglobin D trait do not have health problems related to having the trait.
People with hemoglobin D trait do not have Hemoglobin D disease or sickle cell disease. They cannot develop these diseases later in life. They can pass hemoglobin D trait to their children.
If a person with hemoglobin D trait (hgb AD) has a child with a person with sickle cell trait (hgb AS), they have a 25% chance with each pregnancy to have a child with a form of sickle cell disease called sickle cell D disease or hemoglobin SD disease (hgb SD).
There are also other hemoglobin traits that in combination with sickle cell trait (hgb AS) can create other forms of sickle cell disease. This can include hemoglobin E trait or hemoglobin O trait. People who have these forms of SCD inherit one sickle cell gene (“S”) and one gene from an abnormal type of hemoglobin (“E”, or “O”). Hemoglobin is a protein that allows red blood cells to carry oxygen to all parts of the body. The severity of these rarer types of SCD varies.
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